Table of Contents

Executive Summary        3

Historical Context: A Legacy of Governance Failures at MD Anderson        5

Dr. Padmanee Sharma: A Pattern of Misconduct Enabled by Power        6

Impacts on MD Anderson, Cancer Research, and the NIH        11

Recommendations for Reform        14

Conclusion: A Call for Congressional Oversight        15

Appendix A: Former Senior Executive Blog on MD Anderson Failures        16

Appendix B: 2024 Daily Mail Article Exposed Dr. Sharma        18

Appendix C: Gascar-Robles Email Exchange, July 27-29, 2020        25

Appendix D: Documented Harassment and February 2020 Security Incident        28

Appendix E: Houston Chronicle Articles on Sharma’s Attempt to Steal Credit for Researcher Work        47

Appendix F: Dr. Jamie Lin Letter to the National Institute of Health (NIH)        51

Appendix G: International Scientific Misconduct Expert Support for Dr. Lin        56


Executive Summary

This report, meticulously compiled by a coalition of concerned individuals deeply invested in the integrity of the University of Texas MD Anderson Cancer Center, exposes a profound crisis of leadership and ethical governance at one of the world’s preeminent cancer research institutions. The authors, comprising former and current employees, researchers, and administrators, have chosen anonymity due to the pervasive culture of fear and retribution that has taken root at MD Anderson. The environment within the institution has deteriorated to such an extent that individuals who speak out against misconduct face severe retaliation, including threats to their careers and personal well-being. This toxic atmosphere has necessitated the protection of many identities to ensure that the truth about MD Anderson’s systemic failures can be brought to light without further harm to those who seek justice.

At the heart of this crisis is a deeply broken institution where Dr. Padmanee Sharma, Scientific Director of the Immunotherapy Platform (IMT), has emerged as the primary driver of widespread misconduct, setting a tone of abuse and ethical lapses that has permeated MD Anderson. Under her leadership, a culture of harassment, research misconduct, and obstruction has flourished, involving a network of individuals who are not merely complicit but active participants in perpetuating these wrongs. Dr. James Allison, Sharma’s husband and a Nobel laureate, has facilitated this behavior through his influential role, leveraging his prestige to shield Sharma and amplify her unchecked power. This network includes figures such as Dr. Sumit K. Subudhi, who has engaged in aggressive bullying; administrative staff like Tatianna Robles, Ginger Araujo, and Tiffany Razzo, who have covered up abuses; and senior faculty like Dr. Paul Corn and Dr Nizar M. Tannir, who have failed to intervene, thereby becoming part of the problem.

The crisis at MD Anderson not only jeopardizes its mission but also undermines national efforts to advance cancer research, erodes public trust in federally funded medical institutions, and raises serious questions about the stewardship of taxpayer dollars. The appendices contain extensive documentation—firsthand accounts, email correspondence, and internal communications—that substantiate these allegations and reveal numerous potential whistleblowers whose testimonies could further illuminate the depth of this crisis.

Critically, this pervasive misconduct has been allowed to fester due to the complete failure of oversight by the MD Anderson Board of Regents, the State of Texas, and the Federal Government, all of which have neglected their responsibilities to ensure ethical governance and accountability at an institution entrusted with public funds and the lives of cancer patients worldwide. This committee is urged to convene a congressional hearing within 90 days to examine these allegations, mandate an independent audit of MD Anderson’s leadership and financial practices, and establish whistleblower protections to encourage further testimony.

MD Anderson’s mission to eradicate cancer has been gravely undermined by these actions, which have not only harmed employees but also delayed critical advancements in cancer treatment. This report situates these failures within the broader context of systemic governance issues at MD Anderson, drawing on historical scandals and recent analyses by esteemed organizations such as the National Academy of Medicine (NAM). It calls for immediate congressional oversight to address these violations, protect those who have suffered, and restore the institution’s integrity for the sake of cancer patients worldwide.

The report is structured as follows: it begins with an examination of MD Anderson’s historical governance failures, followed by a detailed analysis of Dr. Sharma’s alleged misconduct, categorized into criminal acts (e.g., workplace harassment, retaliation) and ethical violations (e.g., research misconduct, nepotism, obstruction of research). It then assesses the impacts on MD Anderson, cancer research, and the NIH, offers recommendations for reform, and concludes with a call for action.


Historical Context: A Legacy of Governance Failures at MD Anderson

Institutional Scandals and Systemic Issues

MD Anderson Cancer Center’s current crisis is not an isolated incident but rather the culmination of over a decade of governance failures that have eroded its foundational integrity. In 2017, President Ronald DePinho resigned following a series of financial missteps, including a $267 million operating loss and a failed $62 million partnership with IBM Watson, as documented in a University of Texas System audit reported by The Wall Street Journal in 2017. DePinho’s tenure was further marred by allegations of conflicts of interest involving pharmaceutical companies, a pattern that set a troubling precedent for ethical lapses. The New York Times reported in 2015 that the American Association of University Professors censured MD Anderson for violations of academic freedom during tenure disputes, highlighting a culture of administrative overreach. Len Zwelling, a former MD Anderson administrator, wrote in a 2024 blog post, that The DePinho era exposed a profound lack of accountability among senior leadership, creating fertile ground for the abuses we witness today (see Appendix A: Former Senior Executive Blog on MD Anderson Failures). These historical failures have fostered an environment where figures like Dr. Padmanee Sharma can operate without scrutiny, shielded by institutional prestige and a lack of robust oversight.

The broader context of MD Anderson’s challenges aligns with systemic issues in academic medical centers, as identified by the National Academy of Medicine (NAM). In a 2023 report, NAM explained that academic medical institutions often prioritize prestige and revenue over ethical governance, leading to cultures where misconduct can flourish unchecked. This observation is particularly relevant to MD Anderson, where the pursuit of global recognition has seemingly overshadowed the need for accountability, enabling the patterns of abuse detailed in this report.

Comparative Governance Failures in Academic Medicine

MD Anderson’s governance failures are not unique but reflect a broader pattern in academic medicine where unchecked power leads to systemic abuse. The 2018 University of Southern California (USC) scandal involving Dr. George Tyndall, a gynecologist accused of sexual misconduct over decades, offers a stark parallel. As reported by the Los Angeles Times (2018), USC’s leadership ignored complaints against Tyndall for years, prioritizing institutional reputation over accountability, much like MD Anderson’s handling of Dr. Sharma’s misconduct. The USC case resulted in a $215 million settlement and federal oversight by the Department of Education, leading to significant governance reforms, including mandatory training on ethical conduct and the establishment of an independent ombudsman. The USC case demonstrates that federal oversight, including mandated leadership reforms, can restore institutional integrity, offering a model for addressing MD Anderson’s crisis.


Dr. Padmanee Sharma: A Pattern of Misconduct Enabled by Power

Overview of Allegations and Key Individuals

Dr. Padmanee Sharma, a professor of Genitourinary Medical Oncology and director of scientific programs at the James P. Allison Institute, stands at the center of MD Anderson’s current crisis. While Dr. Sharma has contributed to advancements in immunotherapy, her pattern of misconduct—documented extensively in the appendices—has caused irreparable harm to MD Anderson’s mission and its staff. Her alleged misconduct spans criminal acts and ethical violations, facilitated by her marriage to Nobel laureate Dr. James Allison and their combined influence at MD Anderson (see Appendix B: 2024 Daily Mail Article Exposed Dr. Sharma). Key individuals implicated include:

These allegations, supported by documentation in the appendices, including firsthand accounts, email correspondence, and internal communications, paint a damning picture of Sharma’s influence and the systemic failure to hold her accountable.

Criminal Acts: Workplace Harassment and Retaliation

Dr. Sharma’s actions have crossed legal thresholds, constituting workplace harassment and retaliation in violation of federal labor laws. The appendices provide extensive evidence of a pervasive culture of intimidation at MD Anderson:

These acts violate the Occupational Safety and Health Act (OSHA) by creating a hostile work environment and potentially the Civil Rights Act through discriminatory dismissals. The human toll is severe, with staff reporting mental health crises directly linked to Sharma’s abuse.

Ethical Violations: Research Misconduct, Nepotism, and Obstruction of Scientific Progress

Dr. Sharma’s ethical breaches have profoundly damaged MD Anderson’s integrity and mission, as evidenced by numerous accounts:

These violations betray MD Anderson’s mission, prioritizing personal gain over scientific advancement and patient outcomes, while exploiting power imbalances to target junior researchers.

Leveraging Influence Through James Allison and the Allison Institute

Dr. Sharma’s marriage to Dr. James Allison and their roles at the James P. Allison Institute have amplified her unchecked power. The appendices highlight how their combined influence has skewed resources and opportunities:

This dynamic has created a power structure where ethical oversight is sacrificed to preserve the Allison-Sharma brand, to the detriment of MD Anderson’s mission.

Additional Case: Dr. Jamie Lin’s Experience

Dr. Jamie Lin, a junior researcher, provides a further example of Sharma’s misconduct, though her case is one of many illustrating the broader pattern of abuse at MD Anderson. In a March 13, 2023, letter to the NIH, Lin detailed 18 months of harassment, threats, and bullying by Sharma, Dr. Ala Abudayyeh, and Dr. Adi Diab, beginning with an authorship dispute over a Cancer Immunology Research (CIR) manuscript in August 2021 (see Appendix F: Dr. Jamie Lin Letter to the NIH). Sharma demanded senior authorship despite negligible contributions, threatening Lin’s career if denied (see Appendix F: Dr. Jamie Lin Letter to the NIH). When Lin resisted, Sharma, Abudayyeh, and Diab falsely claimed Lin broke research ethics, obstructing three NIH-funded manuscripts, including placing a JCI Insight manuscript on hold by alleging plagiarism. These allegations were refuted by Dr. Alan Price, a globally recognized expert in scientific misconduct investigations who served from 1989 to 2006 as Scientist-Investigator, Branch Chief, Division Director, and Associate Director for Investigative Oversight at the Office of Research Integrity (ORI), U.S. Department of Health and Human Services (HHS). In his January 5, 2023, review, Price concluded, “Therefore, I conclude there is no basis for apparent allegations of plagiarism of the data in the JCII manuscript from the CIR manuscript, both of which were written by Dr. Lin” (see Appendix G: International Scientific Misconduct Expert Support for Dr. Lin). This finding directly implicates Sharma’s malfeasance in making baseless claims to obstruct Lin’s work, further evidencing her pattern of unethical behavior.

Lin also reported that MD Anderson’s internal review, led by Dr. Barbara Brierer and Mr. Mark Barnes, was biased against her, treating her as the culprit rather than addressing Sharma’s actions NIH (see Appendix F: Dr. Jamie Lin Letter to the NIH). Senior leadership, including Max Weber, Giulio Draetta, Caren Hagberg, Anne Tsao, David Tweardy, and Farhad Danesh, failed to act on Lin’s complaints, enabling ongoing harassment according to the letter. Lin’s experience underscores the systemic issues at MD Anderson, where junior researchers are particularly vulnerable to Sharma’s abuses of power.


Impacts on MD Anderson, Cancer Research, and the NIH

MD Anderson: A Tarnished Legacy

Dr. Sharma’s actions, enabled by complicit HR staff and leadership, have inflicted severe damage on MD Anderson:

Financial Losses at MD Anderson (2020-2025)

Year

Operating Loss

Contributing Factors

2020

$10 million

Early COVID-19 disruptions reduced patient volumes during first half of 2020

2023

$1.6 million

Rising operational costs; moderate patient volume declines

2024

$43 million

Declining patient volume, escalating staffing and operational expenses; heavy investment in immunotherapy projects led by Sharma

Cancer Research: Innovation Stifled

Dr. Sharma’s misconduct has delayed critical advancements in cancer treatment:

NIH: Compromised Integrity

Dr. Sharma’s influence extends to the NIH, undermining its role as a steward of ethical research:


Recommendations for Reform

To address the systemic failures at MD Anderson and prevent similar crises in other institutions, the following actions are recommended:

 

These reforms aim to restore integrity at MD Anderson, protect its staff and researchers, and ensure that cancer research serves the public good.


Conclusion: A Call for Congressional Oversight

Dr. Padmanee Sharma’s tenure at MD Anderson Cancer Center represents a profound betrayal of scientific integrity and ethical leadership, enabled by a complicit renowned faculty (Dr. Paul Corn and Dr. Nizar M. Tannir) and senior leadership (Max Weber, Giulio Draetta, Caren Hagberg, Anne Tsao, David Tweardy, Farhad Danesh), who have shielded her and Dr. Subudhi’s abuses. Her criminal acts—workplace harassment, retaliation, and potential discriminatory dismissals—violate federal laws and demand legal accountability. Her ethical violations—research misconduct, nepotism, and obstruction of scientific progress—have corrupted MD Anderson’s mission, delayed cancer treatments, and harmed countless employees and researchers. Enabled by her husband Dr. James Allison and the James P. Allison Institute, Sharma has operated with impunity, shielded by a complicit administration and potentially influencing the NIH’s investigative processes.

The stakes are nothing less than the lives of cancer patients worldwide. MD Anderson’s legacy, once a beacon of hope, now serves as a cautionary tale of what happens when power goes unchecked in academic medicine. This committee must act swiftly to mandate an independent investigation into MD Anderson’s leadership, focusing on Sharma’s actions and the complicity of HR and senior staff, and review the NIH’s handling of related complaints. With decisive action, MD Anderson can reclaim its status as a global leader in cancer research—a place where innovation thrives, researchers are protected, and patients receive the life-saving treatments they deserve. Congressional intervention can set a precedent for ethical governance in academic medicine, ensuring that institutions entrusted with public funds uphold the highest standards of integrity. Transparency, accountability, and ethical reform are not optional—they are imperatives to restore trust in these institutions and ensure that cancer research serves humanity, not personal ambition. The time for excuses has passed; the time for action is now.



Appendix A: Former Senior Executive Blog on MD Anderson Failures

It is also worth reading the blog of Dr. Leonard Zwelling, the former Vice President for Research Administration at M.D. Anderson, for all his inside information on MD Anderson, but his recent post on June 24, 2025 summarizes the decline of the institution.

An Embarrassment And A Shame

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Appendix B: 2024 Daily Mail Article Exposed Dr. Sharma

This Daily Mail article from May 5, 2024 tipped the scales at MD Anderson, exposing some of the behavior of Dr. Padmanee Sharma and her minions. Other behavior was alluded to, and it was only the tip of the iceberg. 

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Appendix C: Gascar-Robles Email Exchange, July 27-29, 2020

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Appendix D: Documented Harassment and February 2020 Security Incident

Timeline of Harassment and Intimidation Against Jasmine Gascar and Kevin Lagman

The timeline provides a chronological summary of key incidents and complaints at MD Anderson, as recounted by Jasmine Gascar herself, documenting her experiences with harassment and leadership failures.

April 2019 - First month of employment: 

-First meeting with Dr. Sumit Subudhi: He was aggressive, banging on the desk, and abruptly cut me off when I tried to ask any questions, responding with “You obviously don’t know what you are doing if you are asking me those questions.” He also sent messages about how dumb his AA’s (Administrative Assistants) were to his nurse practitioner, Kevin Lagman, my first week which was very intimidating. 

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-First travel coordination handed off to me for Dr. Subudhi, initiated by his previous assistant: Hotel was not confirmed and he arrived to no hotel room and called me yelling and berating me. He followed up with a text: “Know that I am furious!!!” He also followed up with an email to another physician referencing my mistake and how pissed he was about it. I felt humiliated. Reported all of this to my supervisor and nothing was done. 

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June 2019 - HR/Legal Office called me into their office to investigate Dr. Subudhi for aggressive behaviors towards another employee (See screenshot below from HR/Legal office). 

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-After this interview, Dr. Subudhi started acting retaliatory towards me and his clinic team. I reported this to the HR/Legal office - nothing was done. (Below email to HR/Legal regarding concerns for retaliatory behavior. HR/Legal never responded. 

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-Simultaneously, his nurse practitioner, Kevin Lagman, sent this note to his supervisor (And later HR) indicating that he felt there was retaliatory behavior due to his cooperation with the HR/Legal Office investigation of Dr. Subudhi: 

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-Myself and the clinic team are called into a meeting by leadership with Dr. Subudhi so he could “apologize” for his behavior. Nothing changed, this was all for optics. 

-Kevin had to send this document to Kevin’s manager to try defend himself after the terrible email Dr. Subudhi sent to all of leadership trying to justify his behavior towards Kevin. 

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This is the retaliatory email Dr. Subudhi sent trying to ruin Kevin’s reputation AFTER we cooperated with the interviews. 

Conditions continued to deteriorate after this. 

September 2019 - I was assigned to Dr. Sharma. 

-Immediately I was warned about Dr. Sharma’s aggressive behavior by Tatianna Robles, Department Administrator, BEFORE even interacting with her. I was told she had sent a previous assistant to the ER and that I had their support if I needed to be aggressive back with her. 

-Verbal abuse and harassing behavior start from the get go. 

February 2020 – Kevin Langman Panic Attack

-My supervisor, Tiffany Razzo, and Administrative Director, Ginger Araujo, say they will meet with the Chair, Dr, Tannir, to discuss Dr. Subudhi and Sharma’s abusive behavior. Tatianna finds out about the meeting and cancels the meeting shortly after. They then tell me to find another job because this behavior has been going on for years and will not be addressed. 

-Kevin has a panic attack, breakdown after Dr. Subudhi’s abusive behavior. MD Anderson police are called to intervene. 

March 2020 - Email complaints sent to HR and Ombuds. 

-Kevin is finally removed from Dr. Subudhi’s clinic and told he will never have to work with him again. Shortly after he told he will have to cover Dr. Subudhi’s clinic again due to another nurse practitioner being out. 

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April 2020 - Leadership begins sending emails of support for Dr. Subudhi. 

-I witness a conversation with Dr. Sharma and dept leadership indicating leadership needs to do whatever is necessary to “protect Dr. Subudhi”. 

June 2020 - Formal email complaints start being sent by me and my colleagues to Department Leadership. Retaliatory behavior begins soon after. 

-Leadership begins requiring us to come into the office on a rotation to hand deliver the soiled lab coats of clinicians to the laundry room located in the basement. During this time the Institution was discouraging any non-essential personnel from being in the office unless absolutely necessary, however, GU was doing the opposite to us in retaliation for filing formal complaints. These soiled lab coats had been exposed to COVID positive patients-at the time no one knew how transmissible COVID was so we were very scared. We were being required to hand deliver the lab coats without any protective equipment which led me to file a formal safety complaint with the institution. 

-I’m assigned to work on Dr. Subudhi’s promotion. 

July 2020 - Tatianna tries to manipulate me into accepting another apology from Dr. Subudhi.

I decline without HR present and she refuses to have HR present. I go into the office to do the lab coats and Dr. Subudhi approaches me and begins apologizing anyway. I send an email to Tatianna Robles, documenting and copy HR and dept leadership.  I also include Dr. Sharma’s abusive behavior.

Email to Tatianna Robles documenting the abuse (see Appendix C: Gascar-Robles email exchange, July 27-29, 2020)

-Leadership has a meeting with the physicians and tells them about our confidential complaints against them. Physicians ask for all of us to be fired. Conditions deteriorate for all of us who sent email complaints. 

-I begin asking to be removed from Dr. Subudhi and Sharma as I feel unsafe. I am ignored by my supervisor. 

Winter 2020-2021 - I inform my supervisor and Dr. Subudhi and Sharma that I am removing myself from their teams as I do not feel safe any longer. 

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January 2021 - Formal email complaints are sent to Division leadership. HR Gets involved and intimidates us into silence.

Collective email complaints detailing CV incident with Sharma A close-up of a letter

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February 2021 - I finally had to put in my notice because my mental health was suffering. Mass exodus of the rest of my colleagues followed. 

Appendix E: Houston Chronicle Articles on Sharma’s Attempt to Steal Credit for Researcher Work

Two Houston Chronicle Article published on February 9, 2024 and February 16, 2024 reported on Sharma’s attempt to take credit for Dr. Jamie Lin work and the subsequent lawsuit that ensued. See below the February 16, 2024, article.

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Appendix F: Dr. Jamie Lin Letter to the National Institute of Health (NIH)

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Appendix G: International Scientific Misconduct Expert Support for Dr. Lin

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